Welcome to the homepage of the Bordignon group at Ruhr University BochumWe study proteins' conformational changes and dynamic interplay of biomacromolecules in model membranes and in organelles by means of site-directed spin labeling electron paramagnetic resonance (EPR).
This technique bridges the gap between static protein snapshots, which can be provided by crystallographic methods, and dynamic conformational transitions of proteins during their function.
Publication highlight from the Bordignon group: FEBS (2017) doi: 10.1111/febs.14008
The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.
Read the full FEBS article here: http://onlinelibrary.wiley.com/doi/10.1111/febs.14008/abstract
Publication highlight from the Bordignon group: eLife (2017) doi:10.7554/eLife.20236
Exploring conformational equilibria of a heterodimeric ABC transporter.
Read the full eLife article here: https://elifesciences.org/content/6/e20236
Publication highlight from the Bordignon group: Nature (2016) doi:10.1038/nature19757
A complementary approach using X-ray cristallography, DEER, cryo EM and crosslinking unveiled the structure of the Ton complex of E. coli.
Read the full Nature article here: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature19757.html
AMPERE prize 2016
This prize was awarded to Enrica Bordignon at the EUROMAR conference in Aarhus, Denmark on July 3rd.